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Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis

Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 475-479 doi: 10.1007/s11684-009-0086-6

Abstract: The expression of signal transducer and activator of transcription 6 (STAT6) and nuclear factor-κB(NF-κB) in the colonic mucosa of patients with ulcerative colitis (UC) was examined.p65 at both mRNA and protein levels in the colonic mucosa of patients with UC and healthy volunteers.The results showed that the expression levels of STAT6 and NFκB p65 in the colonic mucosa of patientsThese data suggest that STAT6 and NFκB p65 perhaps play an important role in the pathogenesis of

Keywords： ulcerative colitis     signal transducer and activator of transcription 6 (STAT6)     nuclear factor-κ     Bp65 (NF-κ     B p65)    

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Effect of compound Sophorae Flavescentis Jiechangrong capsule on expression of NF-κB p65 and STAT6

Heng FAN MD, Jia ZHAO MM, Lin SHEN BM, Qing TANG MD, Zhexin SHOU MM, Li LIANG BM, Yi LIAO BM, Xiaoyan CHEN BM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 480-484 doi: 10.1007/s11684-009-0083-9

Abstract: compound Sophorae Flavescentis Jiechangrong capsule (CSFJC) on the expression of nuclear factor-κBp65 (NF-κB p65) and signal transducer and activator of transcription 6 (STAT6) in the intestinalAfter the treatment, the expression of NF-κB p65 and STAT6 in the two groups was decreased, andthe decrease of NF-κB p65 and STAT6 expression in TCM group was more significant than in WM groupIt was concluded that CSFJC can inhibit the activation and expression of NF-κB p65 and STAT6 in

Keywords： colitis     ulcerative     compound Sophorae Flavescentis Jiechangrong capsule     nuclear factor-κ     B p65 (NF-κ     B p65)     signal transducer and activator of transcription 6 (STAT6)    

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Inhibition of the nuclear export of p65 and IQCG in leukemogenesis by NUP98-IQCG

Mengmeng Pan,Qiyao Zhang,Ping Liu,Jinyan Huang,Yueying Wang,Saijuan Chen

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 410-419 doi: 10.1007/s11684-016-0489-0

Abstract: <p>NUP98 fuses with approximately 34 different partner genes via translocation in hematologicalNUP98-IQCG with CRM1, and found that NUP98-IQCG expression inhibits the CRM1-mediated nuclear export of p65and enhances the transcriptional activity of nuclear factor-κB.Therefore, the inhibition of nuclear exports of p65 and IQCG might contribute to the leukemogenesis ofp>

Keywords： NUP98-IQCG     nuclear export     NF-κB     CRM1    

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2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2--p65

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 750-766 doi: 10.1007/s11684-021-0839-4

Abstract: this work investigated the mechanisms of SIRT2 in regulating the phosphorylation and acetylation of p65Subsequently, SIRT2 impairment promoted the phosphorylation and acetylation of p65 and activated theThe activation of p65 triggered airway inflammation, increment of mucus secretion by goblet cells, andMeanwhile, p65 phosphorylation and acetylation, airway inflammation, and bronchial hyperresponsivenessTriptolide (a specific p65 inhibitor) reversed p65 activation and ameliorated PM2.5-induced airway inflammation

Keywords： particulate matter 2.5     sirtuin 2     p65     airway inflammation     bronchial hyperresponsiveness     triptolide    

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Impact analysis of compressor rotor blades of an aircraft engine

Y B SUDHIR SASTRY, B G KIROS, F HAILU, P R BUDARAPU

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 3,   Pages 505-514 doi: 10.1007/s11709-018-0493-3

Abstract: Frequent failures due to foreign particle impacts are observed in compressor blades of the interceptor fighter MIG-23 aircraft engines in the Ethiopian air force, supplied by the Dejen Aviation Industry. In this paper, we made an attempt to identify the causes of failure and hence recommend the suitable materials to withstand the foreign particle impacts. Modal and stress analysis of one of the recently failed MIG-23 gas turbine compressor blades made up of the following Aluminum based alloys: 6061-T6, 7075-T6, and 2024-T4, has been performed, apart from the impact analysis of the rotor blades hit by a granite stone. The numerical results are correlated to the practical observations. Based on the modal, stress and impact analysis and the material properties of the three considered alloys, alloy 7075-T6 has been recommended as the blade material.

Keywords： axial flow compressor     rotor and stator blades     aircraft engine     stress and impact analysis     aluminum alloys    

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Non-thermal plasma for exhaust gases treatment

,Marquidia PACHECO P.,Fernando GÓMEZ B.,Joel PACHECO P.,Arturo COLÍN C.,Víctor SÁNCHEZ-MENDIETA,Ricardo VALDIVIA B.,Alfredo SANTANA D.,José HUERTAS C.,Hilda FRÍAS P.

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 3,   Pages 301-305 doi: 10.1007/s11465-015-0344-z

Abstract: <p>This article describes a study on a non-thermal plasma device to treat exhaust gases in an internalp>

Keywords： plasma treatment     NOx     CO     CO2     particulate matter     vehicle    

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Bismuth oxide-related photocatalysts in green nanotechnology: A critical analysis

Andrea P. Reverberi, P.S. Varbanov, M. Vocciante, B. Fabiano

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 4,   Pages 878-892 doi: 10.1007/s11705-018-1744-5

Abstract: A survey addressing the uses of bismuth oxide in photocatalysis is presented. The richness of literature on such a specific topic proves the growing importance of this compound as a valid tool in pollution abatement and environmental decontamination. Many research groups have focused their activity on how to improve the photocatalytic properties of this semiconductor and several solutions have been adopted in the synthesis method, often based on wet-chemical processes. The impressive development of nanoscience helped in understanding and identifying process variables and operative conditions aiming at optimizing the yield of this promising photocatalytic material in the utilization of solar energy.

Keywords： photocatalysis     visible light     bismuth compounds     nanotechnology     environmental remediation     decontamination     pollution abatement    

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Inhibition of NO emission by adding antioxidant mixture in

B. ANAND

Frontiers in Energy 2015, Volume 9, Issue 2,   Pages 238-245 doi: 10.1007/s11708-015-0356-8

Abstract: In this paper, the effect of adding an antioxidant mixture in biodiesel as fuel, in a single cylinder, direct injection compression ignition engine was experimentally investigated and the level of pollutants in the exhaust and performance characteristics of the engine were analyzed. Nine test fuels were prepared with three antioxidants, namely, Succinimide (C H NO ), , dimethyl- -phenylenediamine-dihydrochloride (C H Cl N ), and -phenyl- -phenylenediamine (C H NHC H NH ) added to neat biodiesel at 500 parts per million (ppm), 1000 ppm and 2000 ppm and the observed experimental results were compared with those of neat biodiesel and neat diesel as base fuels. The comparison showed that NO emission was reduced drastically for the test fuels with the antioxidant addition of 2000 ppm. The maximum reduction of 10% of NO emission was observed for the antioxidant mixture in neat biodiesel, with a slight increase in unburned HC, CO and smoke opacity. In addition, the obtained experimental results reveal that the addition of two antioxidants as mixture in neat biodiesel caused improved NO emission reduction for all test fuels.

Keywords： NO emission     antioxidants     Succinimide     N     N-dimethyl-p-phenylenediamine-dihydrochloride     N-phenyl-p-phenylenediamine    

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Performance analysis of new word weighting procedures for opinion mining Article

BRINDHA,P. SWAMINATHAN,B. SANTHI

Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 11,   Pages 1186-1198 doi: 10.1631/FITEE.1500283

Abstract: The proliferation of forums and blogs leads to challenges and opportunities for processing large amounts of information. The information shared on various topics often contains opinionated words which are qualitative in nature. These qualitative words need statistical computations to convert them into useful quantitative data. This data should be processed properly since it expresses opinions. Each of these opinion bearing words differs based on the significant meaning it conveys. To process the linguistic meaning of words into data and to enhance opinion mining analysis, we propose a novel weighting scheme, referred to as inferred word weighting (IWW). IWW is computed based on the significance of the word in the document (SWD) and the significance of the word in the expression (SWE) to enhance their performance. The proposed weighting methods give an analytic view and provide appropriate weights to the words compared to existing methods. In addition to the new weighting methods, another type of checking is done on the performance of text classification by including stop-words. Generally, stop-words are removed in text processing. When this new concept of including stop-words is applied to the proposed and existing weighting methods, two facts are observed: (1) Classification performance is enhanced; (2) The outcome difference between inclusion and exclusion of stop-words is smaller in the proposed methods, and larger in existing methods. The inferences provided by these observations are discussed. Experimental results of the benchmark data sets show the potential enhancement in terms of classification accuracy.

Keywords： Inferred word weight     Opinion mining     Supervised classification     Support vector machine (SVM)     Machine learning    

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A simple umbelliferone based fluorescent probe for the detection of nitroreductase

Bull, Robert B. P. Elmes, Tony D. James

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 2,   Pages 311-314 doi: 10.1007/s11705-017-1697-0

Abstract: A simple nitrobenzyl-umbelliferone (NCOU1) was synthesised containing a nitroreductase (NTR) trigger moiety. The presence of NTR, resulted in the fragmentation of the parent molecule and release of the highly emissive fluorophore umbelliferone an NTR-catalyzed reduction of the nitro group. In the presence of the NTR enzyme, NCOU1 gave rise to a 5-fold increase in fluorescence intensity at 455 nm and was selective for NTR over other reductive enzymes. These results indicate that NCOU1 can be used as a simple assay for the detection of NTR.

Keywords： fragmentation     NCOU1     NTR     nitroreductase     nitrobenzyl-umbelliferone    

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Erratum to: Folded down-conversion mixer for a 60 GHz receiver architecture in 65-nm CMOS technology

Najam Muhammad AMIN,Zhi-gong WANG,Zhi-qun LI

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 5, doi: 10.1631/FITEE.14e0087

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Diporphyrin tweezer for multichannel spectroscopic analysis of enantiomeric excess

Chahal, Václav Březina, Whitney A.Webre, Katsuhiko Ariga, Francis D’Souza, Jan Labuta, Jonathan P. Hill

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1,   Pages 28-40 doi: 10.1007/s11705-019-1869-1

Abstract: Chiral 1,1’-binaphthyl-linked diporphyrin ‘tweezers’ ( )- /( )- and the corresponding zinc(II) complexes ( )- /( )- were prepared as chiral host molecules, and their utility for chiral analyses (especially enantiomeric excess ( ) determinations) were evaluated. Tris(1- -dodecyl)porphyrins were used for the first time as the interacting units. Host capabilities of the diporphyrin tweezers were investigated by titrations with ( , )- and ( , )-cyclohexane-1,2-diamine (CHDA). The host molecules could be used as multichannel probes of by using UV-vis, circular dichroism (CD), fluorescence emission and H nuclear magnetic resonance ( H-NMR) methods. Chiral configurations could also be differentiated using CD or H-NMR spectroscopy. All three optical techniques give good resolution of with reasonable sensitivity considering the low concentrations used (ca. 10 mol·L ). The determination of CHDA enantiomers using NMR spectroscopy is also possible because of the reasonably well separated resonances in the case of ( , )- and ( , )-CHDA. Non-metallated ( )- /( )- hosts could not be used to detect chiral information in a strongly acidic chiral guest. This work demonstrates the utility of 1,1’-binapthyl-linked chiral hosts for chiral analysis of ditopically interacting enantiomers.

Keywords： porphyrin dimer     chirality     enantiomeric excess     CD     fluorescence    

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Synthesis of ［RMIm］PF6（R=P, B, C6）ionic liquid under microwave irradiation and research of its conductivity

He Yongfu

Strategic Study of CAE 2008, Volume 10, Issue 9,   Pages 92-95

Abstract: <p style="text-align: justify;">By microwave irradiation, the intermediate compounds of imidazolium ionicp>

Keywords： ionic liquids     microwave irradiation     conductivity     [BMIm]PF6     [PMIm]PF6     [C6MIm]PF6    

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cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients aged over 65

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 58-67 doi: 10.1007/s11684-022-0937-y

Abstract: This retrospective cohort study recruited 166 lung transplant recipients aged ≥ 65 yearsIn the cohort, subgroups of patients aged 65–70 years (111 recipients, group 65–70) and ≥65 years–70, P = 0.014).was shown to be independently associated with the increased risk of post-LT mortality (HR 6.37, P<

Keywords： cardiac disease     mortality     aged population     lung transplantation    

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Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 232-237 doi: 10.1007/s11705-012-1286-1

Abstract: Three groups of animals were examined respectively for inoculation of inhibitor of p38 MAPK (mitogenLight microscopy, immunohistochemistry, and tensometry revealed that the inhibition of p38 or JNK cascadesSB203580 inhibits the expression of p38, c-Jun and c-Fos.When we have used the JNK blocker, the expression of c-Fos and c-Jun decreased, but the expression of p38

Keywords： connective tissue     mitogen activated protein kinase (MAPK)     p38     JNK    

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Title Author Date Type Operation

Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis

Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,

Journal Article

Effect of compound Sophorae Flavescentis Jiechangrong capsule on expression of NF-κB p65 and STAT6

Heng FAN MD, Jia ZHAO MM, Lin SHEN BM, Qing TANG MD, Zhexin SHOU MM, Li LIANG BM, Yi LIAO BM, Xiaoyan CHEN BM,

Journal Article

Inhibition of the nuclear export of p65 and IQCG in leukemogenesis by NUP98-IQCG

Mengmeng Pan,Qiyao Zhang,Ping Liu,Jinyan Huang,Yueying Wang,Saijuan Chen

Journal Article

2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2--p65

Journal Article

Impact analysis of compressor rotor blades of an aircraft engine

Y B SUDHIR SASTRY, B G KIROS, F HAILU, P R BUDARAPU

Journal Article

Non-thermal plasma for exhaust gases treatment

,Marquidia PACHECO P.,Fernando GÓMEZ B.,Joel PACHECO P.,Arturo COLÍN C.,Víctor SÁNCHEZ-MENDIETA,Ricardo VALDIVIA B.,Alfredo SANTANA D.,José HUERTAS C.,Hilda FRÍAS P.

Journal Article

Bismuth oxide-related photocatalysts in green nanotechnology: A critical analysis

Andrea P. Reverberi, P.S. Varbanov, M. Vocciante, B. Fabiano

Journal Article

Inhibition of NO emission by adding antioxidant mixture in

B. ANAND

Journal Article

Performance analysis of new word weighting procedures for opinion mining

BRINDHA,P. SWAMINATHAN,B. SANTHI

Journal Article

A simple umbelliferone based fluorescent probe for the detection of nitroreductase

Bull, Robert B. P. Elmes, Tony D. James

Journal Article

Erratum to: Folded down-conversion mixer for a 60 GHz receiver architecture in 65-nm CMOS technology

Najam Muhammad AMIN,Zhi-gong WANG,Zhi-qun LI

Journal Article

Diporphyrin tweezer for multichannel spectroscopic analysis of enantiomeric excess

Chahal, Václav Březina, Whitney A.Webre, Katsuhiko Ariga, Francis D’Souza, Jan Labuta, Jonathan P. Hill

Journal Article

Synthesis of ［RMIm］PF6（R=P, B, C6）ionic liquid under microwave irradiation and research of its conductivity

He Yongfu

Journal Article

cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients aged over 65

Journal Article

Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Journal Article